Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms.

Department of Gynecology and Obstetrics, University of Pisa, Pisa, Italy. Queen Charlotte's & Chelsea and Westminster Hospitals and Imperial College, London, The International Menopause Society, London, UK. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Breast Clinic and Menopause Clinic, University Hospital, Gent, Belgium. Department of Women's Health, University Hospitals of Tuebingen, Tuebingen, Germany. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna, Vienna, Austria. Academic Division of Gynecology and Obstetrics, Mauriziano Hospital, University of Turin, Turin, Italy. Department of Obstetrics and Gynecology, Faculty Hospital Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. Department Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Bern, Bern, Switzerland. Department of Gynecology and Obstetrics, Herlev University Hospital, Copenhagen, Denmark. Department of Obstetrics & Gynecology, Mater Dei Hospital, Msida, Malta. New York University School of Medicine, New York, NY, USA. Federación Mexicana de Colegios de Ginecología y Obstetricia (FEMECOG), Mexico, Mexico. Palacios Institute of Women's Health, Madrid, Spain.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2020;(3):190-196

Abstract

Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.

Methodological quality

Publication Type : Review

Metadata